The most common and most likely answer to this crossword clue is the 7 letter word MYSTERY
M
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S
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More clues leading to the result MYSTERY
- Your setter’s singular attempt to pen English puzzle
- Tale, altered in the middle, following the setter’s puzzle
- . Queen entering my hovel expressing puzzlement
- Loveless person giving away nothing in this writer’s thriller
- Shakespeare’s skill, an inexplicable phenomenon
- Conundrum: drug with a title in report?
- Closed book -- whodunnit
- Puzzle as the first person’s tyres burst
- Setter’s enrolling unknown saint and queen to create enigma
- The writer’s tale given a new middle section — detective story?
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MYSTERY mean?
MYSTERY noun- Something secret or unexplainable; an unknown.
- Someone or something with an obscure or puzzling nature.
- A secret or mystical meaning.
- A religious truth not understandable by the application of human reason alone (without divine aid).
- (obsolete outside Eastern Orthodoxy) A sacrament.
- (chiefly in plural) A secret religious celebration, admission to which was usually through initiation.
- A particular event or series of events in the life of Christ.
- A craft, art or trade; specifically a guild of craftsmen.