The most common and most likely answer to this crossword clue is the 6 letter word REGULO
R
E
G
U
L
O
Buddy explains!
The straight part
We know that "Setting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case setting = regulo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does REGULO mean?
REGULO noun- Any of a number of temperatures to which a gas oven may be set. e.g. regulo 4
- A colonially-appointed chief in parts of Africa