Cryptic crossword clue
Seven and up — essentially college careers exam in England 6-4

The most common and most likely answer to this crossword clue is the 11 letter word ELEVEN-PLUS

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Buddy explains!

The straight part
We know that "exam in England" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case exam in england = eleven-plus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ELEVEN-PLUS mean?

ELEVEN-PLUS noun
  1. An examination formerly administered to all students in their final year of primary education, now used only in a few counties of England and Northern Ireland.

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