Cryptic crossword clue
Sexual relationship beginning in Venetian thoroughfare? 6

The most common and most likely answer to this crossword clue is the 6 letter word CARNAL

I've seen this crossword clue in Independent
C
A
R
N
A
L


Buddy explains!

The straight part
We know that "Sexual" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sexual = carnal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CARNAL mean?

CARNAL adjective
  1. Relating to the physical and especially sexual appetites.
  2. Worldly or earthly; temporal.
  3. Of or relating to the body or flesh.

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