Cryptic crossword clue
Shake oil paint apt to run 11

The most common and most likely answer to this crossword clue is the 11 letter word PALPITATION

I've seen this crossword clue in The Times
P
A
L
P
I
T
A
T
I
O
N

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The straight part
We know that "Shake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shake = palpitation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PALPITATION mean?

PALPITATION noun
  1. An abnormal beating of the heart that may be perceived by the patient, a result of excitement, exertion, or illness.

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