The most common and most likely answer to this crossword clue is the 6 letter word CRUETS
I've seen this crossword clue in The Guardian
C
R
U
E
T
S
Buddy explains!
The straight part
We know that "Shakers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shakers = cruets.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CRUETS mean?
CRUETS noun- A small bottle or container used to hold a condiment, such as salt, pepper, oil, or vinegar, for use at a dining table.
- A stand for these containers.
- A small vessel used to hold wine or water for the Eucharist.