Cryptic crossword clue
Shakes off fools wanting date 6

The most common and most likely answer to this crossword clue is the 6 letter word ELUDES

E
L
U
D
E
S

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The straight part
We know that "Shakes off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shakes off = eludes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ELUDES mean?

ELUDES verb
  1. To evade, or escape from someone or something, especially by using cunning or skill
  2. To shake off a pursuer; to give someone the slip
  3. To escape understanding of; to be incomprehensible to

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