Cryptic crossword clue
Sharp American spies returned to protect detectives 6

The most common and most likely answer to this crossword clue is the 6 letter word ACIDIC

A
C
I
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C


Buddy explains!

The straight part
We know that "Sharp" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sharp = acidic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACIDIC mean?

ACIDIC adjective
  1. Having a pH less than 7, or being sour, or having the strength to neutralize alkalis, or turning a litmus paper red.
  2. Containing a high percentage of silica; opposed to basic.
  3. Of or relating to acid; having the character of an acid.

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