Cryptic crossword clue
Shawnee dies trying to protect those most desperate 8

The most common and most likely answer to this crossword clue is the 8 letter word NEEDIEST

I've seen this crossword clue in Financial Times
N
E
E
D
I
E
S
T


Buddy explains!

The straight part
We know that "those most desperate" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case those most desperate = neediest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEEDIEST mean?

NEEDIEST adjective
  1. In need; poor.
  2. Desiring constant affirmation; lacking self-confidence.
  3. Needful; necessary.

Latest crossword clues with full explanations