Cryptic crossword clue
Sherry casks filling señora with local cheer 6

The most common and most likely answer to this crossword clue is the 6 letter word SOLERA

S
O
L
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R
A

Buddy explains!

The straight part
We know that "Sherry casks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sherry casks = solera.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SOLERA mean?

SOLERA noun
  1. A method of producing sherry in which small amounts of younger wines stored in an upper tier of casks are systematically blended with the more mature wine in the casks below
  2. A large wine cask, on the bottom tier in this system, that contains the oldest wine

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