Cryptic crossword clue
She’s beginning to head off to keep appointment and calms down 7

The most common and most likely answer to this crossword clue is the 7 letter word SEDATES

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "calms down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case calms down = sedates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEDATES mean?

SEDATES verb
  1. To calm or put (a person) to sleep using a sedative drug.
  2. To make tranquil.

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