The most common and most likely answer to this crossword clue is the 12 letter word TOBACCONISTS
I've seen this crossword clue in The Daily Telegraph
T
O
B
A
C
C
O
N
I
S
T
S
Buddy explains!
The straight part
We know that "Shopkeepers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shopkeepers = tobacconists.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TOBACCONISTS mean?
TOBACCONISTS noun- A person who sells tobacco, cigarettes, cigars, snuff and sundry items.
- A tobacconist's shop.
- A person who is addicted to smoking tobacco.