The most common and most likely answer to this crossword clue is the 5 plus 6 letter word HUMAN BEINGS
H
U
M
A
N
B
E
I
N
G
S
Buddy explains!
The straight part
We know that "people in general" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case people in general = human beings.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.