Cryptic crossword clue
Sick originally, milk substitute upset baby? 8

The most common and most likely answer to this crossword clue is the 8 letter word SCREAMER

I've seen this crossword clue in Financial Times
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The straight part
We know that "upset baby?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset baby? = screamer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SCREAMER mean?

SCREAMER noun
  1. One who screams; one who shouts; one who sings harshly.
  2. Any bird in the taxonomic family Anhimidae, endemic to South America, being large, bulky birds with a small downy head, long legs and large feet.
  3. A healthy, vigorous animal.
  4. A healthy, vigorous person.
  5. Something exceptionally good.
  6. A difficult catch.
  7. A very hard hit.
  8. A particularly high mark (clean catch of a kicked ball).
  9. A powerful shot.
  10. A very large wave.
  11. A video that unexpectedly frightens the viewer by cutting to a loud scream and disturbing image.
  12. An effeminate gay man; a man who is obviously homosexual.
  13. A bouncer.
  14. An exclamation mark.

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