Cryptic crossword clue
Sickly little girl’s made comfortable 8

The most common and most likely answer to this crossword clue is the 8 letter word DISEASED

I've seen this crossword clue in The Guardian
D
I
S
E
A
S
E
D

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISEASED mean?

DISEASED verb
  1. To cause unease; to annoy, irritate.
  2. To infect with a disease.
DISEASED adjective
  1. Affected with or suffering from disease.

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