Cryptic crossword clue
Sieve cut off, black goop up one on separating process 10

The most common and most likely answer to this crossword clue is the 10 letter word FILTRATION

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does FILTRATION mean?

FILTRATION noun
  1. The act or process of filtering; the mechanical separation of a liquid from the undissolved particles floating in it.
  2. A totally ordered collection of subsets.

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