Cryptic crossword clue
Sign by a road’s contents: illiterate, perhaps 6

The most common and most likely answer to this crossword clue is the 6 letter word IGNARO

I've seen this crossword clue in Independent
I
G
N
A
R
O

Buddy explains!

The straight part
We know that "illiterate, perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case illiterate, perhaps = ignaro.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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