Cryptic crossword clue
Sign of nerves, establishing a connection? 11

The most common and most likely answer to this crossword clue is the 11 letter word HANDSHAKING

I've seen this crossword clue in The Daily Telegraph
H
A
N
D
S
H
A
K
I
N
G

Buddy explains!

The straight part
We know that "establishing a connection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case establishing a connection = handshaking.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HANDSHAKING mean?

HANDSHAKING verb
  1. To perform a handshake; to shake hands.
  2. To perform a handshake with another device.
HANDSHAKING noun
  1. A greeting by clasping hands.
  2. A step in a protocol in which information is exchanged between computing processor devices; often as part of the initiation process for communications.

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