Cryptic crossword clue
Sign of the Spanish in bed, literally laid up 5

The most common and most likely answer to this crossword clue is the 5 letter word TILDE

I've seen this crossword clue in Financial Times
T
I
L
D
E


Buddy explains!

The straight part
We know that "Sign of the Spanish" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sign of the spanish = tilde.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TILDE mean?

TILDE noun
  1. The grapheme of character ~.
  2. The character used to represent negation, usually ~ or ¬.

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