The most common and most likely answer to this crossword clue is the 7 letter word SYMPTOM
I've seen this crossword clue in The Guardian
S
Y
M
P
T
O
M
More clues leading to the result SYMPTOM
- During autopsy, MP to manipulate evidence
- Lousy MP to mask overwhelming evidence of something wrong
- Sign of, for example, kicking out a member – Watson?
- Sign of measles first appears after spot spread across my back
- Sign that Tommy’s upset about Penny
- Hypocrisy, MP to MP – could be a problem here
- Compassion half given on driving test about sign
- Evidence of terrible gyp most absent good minute after
- Indication my MP’s to get sacked
- Tommy’s upset about parking warning sign
Buddy explains!

The straight part
We know that "Sign" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sign = symptom.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SYMPTOM mean?
SYMPTOM noun- A perceived change in some function, sensation or appearance of a person that indicates a disease or disorder, such as fever, headache or rash.
- A signal; anything that indicates, or is characteristic of, the presence of something else, especially of something undesirable.