Cryptic crossword clue
Sign tourists often lack sense 6

The most common and most likely answer to this crossword clue is the 6 letter word INTUIT

I
N
T
U
I
T


Buddy explains!

The straight part
We know that "sense" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sense = intuit.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTUIT mean?

INTUIT verb
  1. To know intuitively or by immediate perception.

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