Cryptic crossword clue
Significantly, teacher leaving school has one supporter 10

The most common and most likely answer to this crossword clue is the 10 letter word MATERIALLY

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Buddy explains!

The straight part
We know that "Significantly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case significantly = materially.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MATERIALLY mean?

MATERIALLY adverb
  1. In a material manner; with regard to physical things or characteristics.
  2. To a significant degree.

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