The most common and most likely answer to this crossword clue is the 2 plus 4 letter word NO DICE
N
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D
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More clues leading to the result NO DICE
- New corset bishop must get out of? Fat chance!
- Signify assent, given sweet dessert? Negative reply
- Slip carelessly on treacherous surface, not a success
- Indicate agreement with reserve, there’s nothing doing
- Denial set in code
- Lack of success upsetting tutor on reserve
- Refusal to move loaf above freezer
- Forget it‘s a way to bid at auction with reserve
- Post-retirement party in French city? Not a chance
- Pleasant to hold back party? Not a success
Buddy explains!

The straight part
We know that "Negative reply" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case negative reply = no dice.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.