Cryptic crossword clue
Signs up to see opening of Sophia Loren play 6

The most common and most likely answer to this crossword clue is the 6 letter word ENROLS

I've seen this crossword clue in Financial Times
E
N
R
O
L
S

Buddy explains!

The straight part
We know that "Signs up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case signs up = enrols.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENROLS mean?

ENROLS verb
  1. To enter (a name, etc.) in a register, roll or list
  2. To enlist (someone) or make (someone) a member of
  3. To enlist oneself (in something) or become a member (of something)
  4. To envelop; to enwrap.

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