The most common and most likely answer to this crossword clue is the 2 plus 4 letter word ON EDGE
I've seen this crossword clue in The Times
O
N
E
D
G
E
More clues leading to the result ON EDGE
- Single digger regularly nervous
- Nervous, being nowhere near the centre
- Wound up hem here?
- Nervous, looking over a cliff?
- Propositioned general, a little uneasy
- Nervous, like one about to dive?
- Third of troopers, say, retreat, upset and nervous
- Nervous study I must keep going over
- Nervous of operating something sharp
- Dragooned gendarme somewhat irritable
Buddy explains!
The straight part
We know that "nervous" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nervous = on edge.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.