Cryptic crossword clue
Sir Isaac’s novel tone curtailed 6

The most common and most likely answer to this crossword clue is the 6 letter word NEWTON

I've seen this crossword clue in The Times
N
E
W
T
O
N


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The straight part
We know that "Sir Isaac" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sir isaac = newton.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEWTON mean?

NEWTON noun
  1. In the International System of Units, the derived unit of force; the force required to accelerate a mass of one kilogram by one metre per second per second. Symbol: N.

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