The most common and most likely answer to this crossword clue is the 12 letter word SOLITARINESS
I've seen this crossword clue in The Times
S
O
L
I
T
A
R
I
N
E
S
S
More clues leading to the result SOLITARINESS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.