The most common and most likely answer to this crossword clue is the 6 letter word KILLER
I've seen this crossword clue in The Daily Telegraph
K
I
L
L
E
R
More clues leading to the result KILLER
- Extremely impressive and hilarious joke
- Ice Queen’s really impressive
- Orca about 45 inches back in the drink
- Queen’s with queen, as king more poorly
- He finishes off game with the queen
- One murdering great joke?
- ‘Skill, eradication’ describes one
- King’s not so good, apparently. Could it be pneumonia?
- Difficult task to drink up measure inside
- King is followed by sicker assassin
Buddy explains!

The straight part
We know that "‘Skill, eradication’ describes one" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ‘skill, eradication’ describes one = killer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does KILLER mean?
KILLER noun- One who or that which kills.
- That which causes stress or is extremely difficult, especially that which may cause failure at a task.
- Something that is so far ahead of its competition that it effectively kills off that competition.
- A knockout form of darts or pool involving several players.
- A club used for killing fish.
- A particularly heavy type of handstamp, or portion of one, often obscuring a large part of the postage stamp.
- A diacritical mark used in Indic scripts to suppress an inherent vowel (e.g., the Hindi viram, the Bengali or Oriya hasanta) or render the entire syllable silent (e.g., the Burmese virama, the Khmer toandakhiat).
- Excellent, very good, cool.
- Causing death, destruction, or obliteration.
- Distressing, uncomfortable.
- A sea mammal related to dolphins and porpoises (Orcinus orca).