The most common and most likely answer to this crossword clue is the 5 letter word PINTA
P
I
N
T
A
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The straight part
We know that "Skin discoloration/drink generally" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skin discoloration/drink generally = pinta.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PINTA mean?
PINTA noun- A pint of milk.
- A human skin disease endemic to Mexico, Central America, and South America, caused by infection with a spirochete, Treponema pallidum carateum, which is morphologically and serologically indistinguishable from the organism that causes syphilis.
- (Chicano) prison