Cryptic crossword clue
Skinny vermin almost entirely squashed by upstanding cardinal 6

The most common and most likely answer to this crossword clue is the 6 letter word DERMIC

I've seen this crossword clue in The Guardian
D
E
R
M
I
C

Buddy explains!

The straight part
We know that "Skinny" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skinny = dermic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DERMIC mean?

DERMIC adjective
  1. Of or relating to the dermis or skin.

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