Cryptic crossword clue
Skin’s burning up — pain in Nice 6

The most common and most likely answer to this crossword clue is the 6 letter word DERMAL

I've seen this crossword clue in The Daily Telegraph
D
E
R
M
A
L

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DERMAL mean?

DERMAL adjective
  1. Of or pertaining to skin or integument (or other forms of tissue)

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