Cryptic crossword clue
Slander American woman, European female intervening 6

The most common and most likely answer to this crossword clue is the 6 letter word DEFAME

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Slander" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case slander = defame.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEFAME mean?

DEFAME noun
  1. Disgrace, dishonour.
  2. Defamation; slander, libel.
DEFAME verb
  1. To disgrace; to bring into disrepute.
  2. To charge; to accuse (someone) of an offence.
  3. To harm or diminish the reputation of; to disparage.

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