Cryptic crossword clue
Slip out of place, as role is miscast 8

The most common and most likely answer to this crossword clue is the 8 letter word PROLAPSE

P
R
O
L
A
P
S
E

Buddy explains!

The straight part
We know that "Slip out of place" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case slip out of place = prolapse.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROLAPSE mean?

PROLAPSE noun
  1. A moving out of place, especially a protrusion of an internal organ
PROLAPSE verb
  1. To move out of place; especially for an internal organ to protrude beyond its normal position.

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