The most common and most likely answer to this crossword clue is the 10 letter word CHICKENPOX
I've seen this crossword clue in The Times
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More clues leading to the result CHICKENPOX
Buddy explains!

The straight part
We know that "an infectious thing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case an infectious thing = chickenpox.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHICKENPOX mean?
CHICKENPOX noun- A common childhood disease caused by the varicella zoster virus (VZV), Human alphaherpesvirus 3 (HHV-3).