Cryptic crossword clue
Smile and leave American to Mexican 6

The most common and most likely answer to this crossword clue is the 6 letter word GRINGO

I've seen this crossword clue in The Guardian
G
R
I
N
G
O

Buddy explains!

The straight part
We know that "American to Mexican" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case american to mexican = gringo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GRINGO mean?

GRINGO noun
  1. A white person from an English-speaking country, particularly the United States.

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