The most common and most likely answer to this crossword clue is the 8 letter word MOCCASIN
I've seen this crossword clue in The Daily Telegraph
M
O
C
C
A
S
I
N
More clues leading to the result MOCCASIN
- What’s afoot minutes before event in which second round’s lost
- Maiden happening to lose old shoe
- Say coffee’s popular? I may wear that
- Snakeskin shoe?
- Soft leather shoe? We hear soft leather has something wrong with it
- Maiden having opportunity to discard old slipper
- Snake coffee’s trendy, reportedly
- Shoe that’s in snakeskin
- Poisoner that’s afoot?
- Male on time, none the less, producing leather shoe
Buddy explains!

The straight part
We know that "Snake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case snake = moccasin.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MOCCASIN mean?
MOCCASIN noun- A traditional Native North American shoe, usually without a heel or sole, made of a piece of deerskin or other soft leather turned up at the edges which are either stitched together at the top of the shoe, or sewn to a vamp (a piece covering the top of the foot).
- A modern shoe with either a low or no heel resembling a traditional Native American moccasin in that the leather forming the sides of the shoe is stitched at the top.
- A light beige colour, like that of a moccasin.
- Any of several North American snakes of the genus Agkistrodon, particularly the copperhead (Agkistrodon contortrix) and the cottonmouth or water moccasin (Agkistrodon piscivorus).