Cryptic crossword clue
Socially inept duke invested in Tyneside railway 5

The most common and most likely answer to this crossword clue is the 5 letter word NERDY

I've seen this crossword clue in Independent
N
E
R
D
Y


Buddy explains!

The straight part
We know that "Socially inept" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case socially inept = nerdy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NERDY mean?

NERDY adjective
  1. (of a person) Being or like a nerd.
  2. (of a quality or interest) Of, pertaining to, in the style of, or appealing to nerds.

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