The most common and most likely answer to this crossword clue is the 13 letter word QUADRUPLICATE
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More clues leading to the result QUADRUPLICATE
Buddy explains!
The straight part
We know that "once, then again and again and again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case once, then again and again and again = quadruplicate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does QUADRUPLICATE mean?
QUADRUPLICATE noun- In quadruplicate: four times over, in four copies
- To replicate four times; to make fourfold; to quadruple.
- Having four parts
- Four times over, multiplied by four