Cryptic crossword clue
Somewhere in Hants, old duke leaves room upset 8

The most common and most likely answer to this crossword clue is the 8 letter word RINGWORM

R
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N
G
W
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M


Buddy explains!

The straight part
We know that "upset" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset = ringworm.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RINGWORM mean?

RINGWORM noun
  1. A contagious fungal infection of the skin, characterised by ring-shaped discoloured patches, covered by vesicles or scales.

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