The most common and most likely answer to this crossword clue is the 6 letter word SAGEST
I've seen this crossword clue in The Daily Telegraph
S
A
G
E
S
T
More clues leading to the result SAGEST
- Most wise and godly person having a long time inside
- It’s most wise to decline drugs on start of tour
- Most wise old men are on the square
- Most learned maybe with coaches taking time to finish
- Son fixed gates — that’s most wise
- Most discerning characters of this age stifled
- Most intelligent son gets a new form
- Wisest saint grows older inside
- Most judicious saint taking a very long time
- Bends down, at first; that's wisest
Buddy explains!
The straight part
We know that "most wise" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most wise = sagest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.