Cryptic crossword clue
Son put into river in a box is treated with disrespect 10

The most common and most likely answer to this crossword clue is the 10 letter word DESECRATED

I've seen this crossword clue in The Times
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The straight part
We know that "treated with disrespect" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case treated with disrespect = desecrated.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESECRATED mean?

DESECRATED verb
  1. To profane or violate the sacredness or sanctity of something.
  2. To remove the consecration from someone or something; to deconsecrate.
  3. To change in an inappropriate and destructive way.

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