Cryptic crossword clue
Son very sadly vacuous being 22 can make you so!

The most common and most likely answer to this crossword clue is the 7 letter word STRESSY

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "being 22 can make you so!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case being 22 can make you so! = stressy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STRESSY mean?

STRESSY adjective
  1. Stressful
  2. Stressed; irritable

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