Cryptic crossword clue
Sons use drug company rearing spiders? 8

The most common and most likely answer to this crossword clue is the 8 letter word OCTOPODS

O
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The straight part
We know that "spiders?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spiders? = octopods.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OCTOPODS mean?

OCTOPODS noun
  1. Any animal with eight feet or foot-like parts.
  2. Any cephalopod mollusks of the order Octopoda.
  3. A railway locomotive with eight wheels.

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