The most common and most likely answer to this crossword clue is the 6 letter word LESION
I've seen this crossword clue in The Times
L
E
S
I
O
N
More clues leading to the result LESION
Buddy explains!
The straight part
We know that "Sore" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sore = lesion.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LESION mean?
LESION noun- A wound or injury.
- An infected or otherwise injured or diseased organ or part, especially such on a patch of skin.
- Any compound formed from damage to a nucleic acid.
- Injury or an unfair imbalance in a commutative contract wherein the consideration is less than half of the market value, which then serves as a basis for the injured party to sue to rescind the agreement.
- To wound or injure, especially in an experiment or other controlled procedure.