Cryptic crossword clue
Soul of personal assistant bishop’s ignored 5

The most common and most likely answer to this crossword clue is the 5 letter word ATMAN

A
T
M
A
N

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The straight part
We know that "Soul" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case soul = atman.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ATMAN mean?

ATMAN noun
  1. (Vedanta) The true self of an individual beyond identification with worldly phenomena, the essence of an individual, an infinitesimal part of Brahman.

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