Cryptic crossword clue
Soured ale put in middle of remedy 10

The most common and most likely answer to this crossword clue is the 10 letter word EMBITTERED

E
M
B
I
T
T
E
R
E
D

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMBITTERED mean?

EMBITTERED verb
  1. To cause to be bitter.

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