Cryptic crossword clue
South American killer has a sting to pierce duck 8

The most common and most likely answer to this crossword clue is the 8 letter word ANACONDA

I've seen this crossword clue in Financial Times
A
N
A
C
O
N
D
A


Buddy explains!

The straight part
We know that "South American killer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case south american killer = anaconda.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANACONDA mean?

ANACONDA noun
  1. Any of various large nonvenomous snakes of the genus Eunectes, found mainly in northern South America. Their length can grow to as much as 5 m (15 ft).
  2. (by extension) A large penis.
ANACONDA proper noun
  1. A particular variety of stud poker.

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