Cryptic crossword clue
Sozzled, Thelma’s drinking no spirit 8

The most common and most likely answer to this crossword clue is the 8 letter word METHANOL

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The cryptic/wordplay part
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What does METHANOL mean?

METHANOL noun
  1. The simplest aliphatic alcohol, CH3OH; a colourless, toxic, inflammable liquid, used as a solvent, antifreeze, in the chemical industry, and in the preparation of methylated spirit.

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