The most common and most likely answer to this crossword clue is the 6 letter word TOLEDO
I've seen this crossword clue in The Sunday Telegraph
T
O
L
E
D
O
More clues leading to the result TOLEDO
- Fuss about the French in Spanish city
- Spanish city shepherded in as well
- Reflective poem set in Spanish city
- Informed Ohio about drug manufacturing centre there
- Spanish city coming up in postcode lottery
- City of the Spanish upset in agitation
- Excitement about return of the Spanish sword
- Commotion across the French city
- The French trapped by fuss in Spanish city
- City to announce general pastry ingredient
Buddy explains!

The straight part
We know that "Spanish city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spanish city = toledo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.