The most common and most likely answer to this crossword clue is the 8 letter word PEPPERED
I've seen this crossword clue in The Times
P
E
P
P
E
R
E
D
More clues leading to the result PEPPERED
Buddy explains!

The straight part
We know that "Spiced up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spiced up = peppered.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PEPPERED mean?
PEPPERED verb- To add pepper to.
- To strike with something made up of small particles.
- To cover with lots of (something made up of small things).
- To add (something) at frequent intervals.
- Seasoned with pepper.
- Speckled.